dial a shaman

  TWiN explains the finding that activation of intracellular, not plasma membrane, serotonin 2A receptors is responsible for the plasticity-promoting and antidepressant-like properties of psychedelic compounds. https://www.youtube.com/watch?v=YAAcHy8eaTQ  ...  RE-ASSURING FOOTNOTE ... these people are not lightweights & they will widen your vocabulary.       ...    ASPIRATIONAL FOOTNOTE ... it is never too late to wise up on neuroscience ... you will possibly understand yourself & the rest of humanity a little more clearly.

  https://www.theguardian.com/science/2026/apr/06/scientists-identify-neural-fingerprint-of-psychedelic-drugs-in-the-brain the published paper ... https://www.nature.com/articles/s41591-026-04287-9 Abstract Psychedelic drugs are re-emerging as promising scientific and clinical tools. However, despite a rapidly expanding literature on their therapeutic value, the neural mechanisms underlying psychedelic effects remain unclear. Resting-state functional magnetic resonance imaging studies of acute psychedelic effects, conducted independently by several research groups, have so far yielded fragmented and sometimes inconsistent findings. Here, to help facilitate greater convergence, we conducted a ‘mega-analysis’ integrating 11 independent resting-state functional magnetic resonance imaging datasets across five psychedelic drugs (psilocybin, lysergic acid diethylamide, mescaline,  N , N -dimethyltryptamine and ayahuasca) from research groups spanning three continents and five countr...