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YET MORE GOOD NEWS ABOUT PSILOCYBIN ... SOME EXTRAORDINARILY THOROUGH RESEARCH

https://www.nature.com/articles/s41467-026-71962-3 Abstract Psychedelics have robust effects on acute brain function and long-term behavior but whether they also cause enduring functional and anatomical brain changes is largely unknown. In an exploratory, placebo-controlled, within-subjects, electroencephalography (EEG), and magnetic resonance imaging (MRI) study in 28 healthy, entirely psychedelic-naive participants, anatomical and functional brain changes are detected from one-hour to one-month after a single high-dose (25 mg) of psilocybin. Increases in cognitive flexibility, psychological insight, and well-being are seen at one-month. Diffusion tensor imaging (DTI) done before and one-month after 25 mg psilocybin reveals decreased axial diffusivity bilaterally in prefrontal-subcortical tracts that correlate with decreases in brain network modularity (fMRI) over the same month. Enduring functional brain changes are largely absent, but network modularity change (numerical decrease) n...
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research continues into the effects that psychedelic drugs have on brain cell connectors ... seems promising

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  https://www.theguardian.com/science/2026/apr/06/scientists-identify-neural-fingerprint-of-psychedelic-drugs-in-the-brain the published paper ... https://www.nature.com/articles/s41591-026-04287-9 Abstract Psychedelic drugs are re-emerging as promising scientific and clinical tools. However, despite a rapidly expanding literature on their therapeutic value, the neural mechanisms underlying psychedelic effects remain unclear. Resting-state functional magnetic resonance imaging studies of acute psychedelic effects, conducted independently by several research groups, have so far yielded fragmented and sometimes inconsistent findings. Here, to help facilitate greater convergence, we conducted a ‘mega-analysis’ integrating 11 independent resting-state functional magnetic resonance imaging datasets across five psychedelic drugs (psilocybin, lysergic acid diethylamide, mescaline,  N , N -dimethyltryptamine and ayahuasca) from research groups spanning three continents and five countr...
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benevolent psilocin possibly maybe ... probably !

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  https://www.nature.com/articles/s41514-025-00244-x Abstract Psilocybin, the naturally occurring psychedelic compound produced by hallucinogenic mushrooms, has received attention due to considerable clinical evidence for its therapeutic potential to treat various psychiatric and neurodegenerative indications. However, the underlying molecular mechanisms remain enigmatic, and few studies have explored its systemic impacts. We provide the first experimental evidence that psilocin (the active metabolite of psilocybin) treatment extends cellular lifespan and psilocybin treatment promotes increased longevity in aged mice, suggesting that psilocybin may be a potent geroprotective agent. https://en.wikipedia.org/wiki/Psilocin
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